Endocrine Abstracts

Vitamin D has become an important player beyond bone and calcium metabolism. Receptors for 1,25(OH)2D3 or calcitriol as well as the machinery to produce 1,25(OH)2D3 locally are present all over the immune system. Regulation of the enzyme responsible for the final activation of 1,25-dihydroxyvitamin D3 (CYP27B1) is however completely different in immune cells than in kidney cells. Particular immunomodulating effects of 1,25...